Research themes

Research themes must meet a set of essential criteria:

• Address a research target that is likely to be crucial to the prevention of preterm birth.
• Generate or refine new technologies that could lead to important new discoveries regarding preterm birth.
• Leverage the expertise and resources available across all the Ohio Collaborative medical centers, hospitals and universities.
• Provide a strong foundation for transdisciplinary collaboration.

The March of Dimes Prematurity Research Center Ohio Collaborative will address five inter-related transdisiciplinary research themes:

Rokas 135X2

Evolutionary Synthesis of Human Pregnancy This theme is a comprehensive synthesis of molecular, physiologic and evolutionary information that will generate a unique resource for investigators in reproductive biology worldwide called GEneSTATION.
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Theme Leaders and Co-Investigators & Collaborating Faculty >


Williams 135X135

Genetics of Unique Human Populations Genetics vary in both human birth timing and preterm birth. These variations will be identified and used to understand ancestry-birth timing that differ across existing populations in a micro evolutionary approach.
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Theme Leaders and Co-Investigators & Collaborating Faculty >


Muglia 135X135

The Molecular Developmental Biology of Pregnancy This research theme will seek to define maternal-fetal signals that establish and define the long-term outcomes of pregnancy.
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Theme Leaders and Co-Investigators & Collaborating Faculty >


Mesiano 135X135

Progesterone Signaling in Pregnancy Maintenance and Preterm BirthThe investigators will integrate a complex synthesis of genetically engineered cellular systems, human gestational tissues and computationally intensive systems biology approaches to shed new insight into the networks that define birth timing.
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Theme Leaders and Co-Investigators & Collaborating Faculty >


Dr. Irina Buhimschi

Sociobiology of Racial Disparities in Preterm Birth This theme will test the hypothesis that racial disparity in preterm birth results from the overall impact of sociologic, environmental and biomedical stressors moderated by individual psychosocial and physiologic resilience.
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Theme Leaders and Co-Investigators & Collaborating Faculty >