Sundeep Kalantry, PhD

Professor | University of Michigan Medical School
March of Dimes
Sundeep Kalantry

Sundeep Kalantry, PhD, Professor, University of Michigan Medical School  
Website: https://kalantry.lab.medicine.umich.edu/ 

Biography

Dr. Sundeep Kalantry's goals are to inspire students and trainees to investigate epigenetic processes that result in proper embryonesis. He's a Professor of Human Genetics at the University of Michigan. Dr. Kalantry’s lab’s primary research focus is unraveling the genetic and epigenetic underpinnings of X-chromosome inactivation. In X-inactivation, genes on one of the two identical or nearly-identical X chromosomes in female cells are silenced to equalize X-linked gene expression between females and males. How one X in female cells is silenced but the other remains transcriptionally active in the same small space of the nucleoplasm fascinates Dr. Kalantry. His lab has discovered drivers of X-inactivation, which in the future may allow for the control of X-linked gene expression for therapeutic purposes in girls. Dr. Kalantry is a co-founder of the University of Michigan’s Chromatin Club and serves as the Associate Director of an NIH-funded predoctoral fellowship grant in reproductive biology. His lab has been funded by the NIH, the Ellison Medical Foundation, and March of Dimes.

Education

AB Biochemistry, Cornell University (1993)

PhD Molecular Biology, Weill Medical College of Cornell University (2001)

PhDs Neuroscience, Montpellier University 2, France, Cum Laude (2010)

PhD Biochemistry, Autonomous University of Barcelona, Spain, European Mention (2010)

Honors and recognition

NIH Pathway to Independence Award (2007)

NIH Director's New Innovator (2011)

Ellison Medical Foundation New Scholar In Aging Award (2011)

March of Dimes Basil O'Connor Starter Scholar Research Award (2011)

March of Dimes Research (2018)

Selected publications

  1. Samanta MK*, Gayen G*, Harris C, Maclary E, Murata-Nakamura Y, Malcore RM, Porter RS, Garay PM, Vallianatos C, Samollow PB, Iwase S, and Kalantry S. Activation of Xist by an Evolutionarily Conserved Function of the KDM5C Demethylase. Nature Communications May 11;13:2602 (2022). PubMed PMID: 35545632. PubMed Central PMCID: PMC9095838. *, co-first authors.
  2. Cloutier M*, Kumar S*, Buttigieg E*, Keller L, Lee B, Williams A, Mojica-Perez S, Erliandri I, Rocha AMD, Cadigan K, Smith GD, and Kalantry S. Preventing Erosion of X-chromosome Inactivation in Human Embryonic Stem Cells. Nature Communications May 6;13:2516 (2022). PubMed PMID: 35523820. PubMed Central PMCID: PMC9076865. *, co-first authors.
  3. Harris C*, Cloutier M*, Trotter M, Hinten M, Gayen S, Du Z, Xie W, Kalantry, S. Conversion of Random X-inactivation to Imprinted X-inactivation by Maternal PRC2. eLife 2019 Apr 2;8:e44258:1-30. PubMed PMID: PM30938678. PubMed Central PMCID: PMC6541438. *, co-first authors.
  4. Cloutier M, Harris C, Gayen S, Maclary E, Kalantry S. Experimental Analysis of Imprinted Mouse X-Chromosome Inactivation. Methods Mol Biol. 2018;1861:177-203. PubMed PMID: 30218368; PubMed Central PMCID: PMC6209079.
  5. Maclary E, Hinten M, Harris C, Sethuraman S, Gayen S, Kalantry S. PRC2 represses transcribed genes on the imprinted inactive X chromosome in mice. Genome Biol. 2017 May 3;18(1):82. PubMed PMID: 28468635; PubMed Central PMCID: PMC5415793.
  6. Gayen S, Maclary E, Hinten M, Kalantry S. Sex-specific silencing of X-linked genes by the Xist RNA. Proceedings of the National Academy of Sciences of the U.S.A. 2016 Jan 19;113(3):E309-18. PubMed PMID: 26739568; PubMed Central PMCID: PMC4725534.
  7. Hinten M, Maclary E, Gayen S, Harris C, Kalantry S. Visualizing Long Noncoding RNAs on Chromatin. Methods Mol Biol. 2016;1402:147-164. PubMed PMID: 26721489; PubMed Central PMCID: PMC5094191.
  8. Sarkar MK, Gayen S, Kumar S, Maclary E, Buttigieg E, Hinten M, Kumari A, Harris C, Sado T, Kalantry S. An Xist-activating antisense RNA required for X-chromosome inactivation. Nature Communications 2015 Oct 19;6:8564. PubMed PMID: 26477563; PubMed Central PMCID: PMC4616153.
  9. Gayen S, Maclary E, Buttigieg E, Hinten M, Kalantry S. A Primary role for the Tsix lncRNA in maintaining random X-chromosome inactivation. Cell Reports 2015 May 26;11(8):1251-65. PubMed PMID: 25981039; PubMed Central PMCID: PMC4449283.
  10. Maclary E, Buttigieg E, Hinten M, Gayen S, Harris C, Sarkar MK, Purushothaman S, Kalantry S. Differentiation-dependent requirement of Tsix long non-coding RNA in imprinted X-chromosome inactivation. Nature Communications 2014 Jun 30;5:4209. PubMed PMID: 24979243; PubMed Central PMCID: PMC4086345.

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