Ripla Arora, PhD

Associate Professor | Michigan State University
March of Dimes
Ripla Arora

Ripla Arora, Associate Professor, Michigan State University, 
Lab website: www.aroralab.com

Biography

Dr. Ripla Arora is a developmental biologist who seeks to understand the signaling mechanisms that underlie organ shape and tissue morphogenesis. Using quantitative image analysis and developmental genetics she investigates the ovarian hormone-driven signaling mechanisms that shape the three-dimensional uterine structure necessary to facilitate embryo attachment during early pregnancy. Her Basil O’Connor Starter Scholar research award from March of Dimes focused on investigating the impact of pain medications (non-steroidal anti-inflammatory drugs) on uterine gland shape and embryo implantation. Her long-term vision is to define novel players responsible for early pregnancy success from a structure-function perspective to facilitate new approaches for optimizing embryo implantation and improving outcomes for clinical paradigms that cause compromised fetal development. Her lab is funded by NIH and March of Dimes.

Education

BS, Biochemistry, Delhi University (2003) 

MS, Biochemistry, Delhi University (2005) 

MA, Genetics and Development, Columbia University (2006) 

PhD, Genetics and Development, Columbia University (2012) 

Honors and recognition

Society for Study of Reproduction Rising Star (2023)

Jean P Schultz Biomedical Research Award (2022)

Basil O'Connor Starter Scholar Research Award, March of Dimes (2020)

Selected publications

  1. Massri N, Loia R, Sones JL, Arora R*, Douglas NC* (2023). Vascular Changes in the cycling and early pregnant uterus. Journal of Clinical Investigation, Insight. JCI Insight. 8(11):e163422. doi: 10.1172/jci.insight.163422. PMID: 37288662.
  2. Xu QX, Madhavan M, Wei SW, Zhang WQ, Lu L, Wang KZ, Zhao Y, Shao HT, Kang JW, Fazleabas AT*, Arora R*, Su RW* (2023). Aberrant activation of Notch1 signaling in the mouse uterine epithelium promotes hyperplasia by increasing estrogen sensitivity. FASEB J. 37(7):e22983. doi: 10.1096/fj.202201868RR. PMID: 37249327.
  3. Lufkin H, Flores D, Raider Z, Madhavan M, Dawson M, Coronel A, Sharma D, Arora R* (2022). Pre-implantation mouse embryo movement under hormonally altered conditions. Mol Hum Reprod. doi: 10.1093/molehr/gaac043. PMID: 36579867.
  4. Madhavan M, DeMayo FJ, Lydon JP, Joshi NR, Fazleabas AT, Arora R* (2022). Aberrant uterine folding in mice disrupts implantation chamber formation and embryo-uterine axes alignment. Development. 149(11):dev200300. doi: 10.1242/dev.200300. PMID: 35575097.
  5. Khan S, Fitch S, Knox S, Arora R* (2022). Exocrine gland structure-function relationships. Development. 149(1):dev197657. PMID: 34989394.
  6. Marquardt RM, Kim TH, Yoo JY, Teasley HE, Fazleabas AT, Young SL, Lessey BA, and Arora R* and Jeong JW* (2021). Endometrial epithelial 1 ARID1A is critical for uterine gland function in early pregnancy establishment. FASEB J. 35(2):e21209. PMID: 33222288.
  7. Flores D, Madhavan M, Wright S, Arora R* (2020). Mechanical and signaling mechanisms that guide preimplantation embryo movement. Development. 147(24):dev193490. PMID: 33158924.

Weblinks