Prasanna Jagannathan, MD

Assistant Professor | Stanford University School of Medicine
March of Dimes
Prasanna Jagannathan

Prasanna Jagannathan, MD, Assistant Professor of Medicine and of Microbiology and Immunology, Stanford University School of Medicine
Website: https://med.stanford.edu/jagannathan-lab.html 

Biography

Dr. Prasanna Jagannathan’s work focuses on correlates and mechanisms driving naturally acquired immunity to malaria in young children and pregnant women. His laboratory is focused on determining how, following repeated exposure to malaria parasites, individuals are eventually able to tolerate malaria parasitemia without developing symptoms. His work as a March of Dimes Basil O’Connor Scholar aimed to understand how repeated malaria induces regulation of both innate and adaptive immune cells in young chidren and pregnant women. He is also curious about how interventions that prevent exposure to malaria parasites—such as antimalarial chemoprevention—might impact the development of naturally acquired immunity to malaria. His work has been performed in close collaboration with investigators from the Ugandan Infectious Diseases Research Collaboration. During the COVID-19 pandemic, he led similar studies of immune modifying interventions for SARS-CoV-2, and he and his collaborators utilized samples collected from those studies to better understand SARS-CoV-2 immunopathogenesis.

Education

BA Religious Studies, University of California, Berkeley (1998)

MD Harvard University, Medicine (2005)

Residency, University of California, San Francisco, Internal Medicine (2009)

Fellowship, University of California, San Francisco, Infectious Diseases (2011)

Postdoctoral Training, University of California, San Francisco, Immunology (2012)

Certificate, University of California, San Francisco, Advanced Training in Clinical Research (2014)

Honors and recognition

Stanford Maternal and Child Health Research Institute Faculty Scholar Award (2023)

March of Dimes Basil O’Connor Award (2019)

New Investigator Award from the Society for Behavioral Neuroendocrinology (2017)

Stanford University Rosenkranz Prize (2018)

American Society of Clinical Investigation Young Physician-Scientist Award (2018)

Certificate, University of California, San Francisco, Advanced Training in Clinical Research (2014)

Selected publications

  1. Ty M, Sun S, Callaway PC, Rek J, Press KD, van der Ploeg K, Nideffer J, Hu Z, Klemm S, Greenleaf WJ, Donato M, Tukwasibwe S, Arinaitwe E, Nankya F, Musinguzi K, Andrew D, de la Parte L, Mori D, Lewis SN, Takahashi S, Rodriguez-Barraquer I, Greenhouse B, Blish C, Utz PJ, Khatri P, Dorsey G, Kamya M, Boyle MJ, Feeney M, Ssewanyana I, Jagannathan P. Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria. Sci Transl Med. 2023 Jan 25;15(680):eadd9012. doi: 10.1126/scitranslmed.add9012. Epub 2023 Jan 25. PMID: 36696483.
  2. Nideffer J, Ty M, Donato M, John R, Kajubi R, Ji X, Maecker H, Nankya F, Musinguzi K, Press KD, Greenhouse B, Kamya M, Feeney ME, Dorsey G, Utz P, Pulendran B, Khatri P, Jagannathan P. Disease Tolerance Acquired Through Repeated Plasmodium Infection Involves Epigenetic Reprogramming of Innate Immune Cells. bioRxiv. 2023:2023.04.19.537546. doi: 10.1101/2023.04.19.537546.
  3. Hu Z, van der Ploeg K, Chakraborty S, Arunachalam PS, Mori DAM, Jacobson KB, Bonilla H, Parsonnet J, Andrews JR, Holubar M, Subramanian A, Khosla C, Maldonado Y, Hedlin H, de la Parte L, Press K, Ty M, Tan GS, Blish C, Takahashi S, Rodriguez-Barraquer I, Greenhouse B, Butte AJ, Singh U, Pulendran B, Wang TT, Jagannathan P. Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study. Elife. 2022;11. Epub 2022/10/15. doi: 10.7554/eLife.77943. PubMed PMID: 36239699; PMCID: PMC9566856.
  4. Chan JA, Loughland JR, de la Parte L, Okano S, Ssewanyana I, Nalubega M, Nankya F, Musinguzi K, Rek J, Arinaitwe E, Tipping P, Bourke P, Andrew D, Dooley N, SheelaNair A, Wines BD, Hogarth PM, Beeson JG, Greenhouse B, Dorsey G, Kamya M, Hartel G, Minigo G, Feeney M, Jagannathan P, Boyle MJ. Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children. Nat Commun. 2022 Jul 18;13(1):4159. doi: 10.1038/s41467-022-31880-6. PMID: 35851033; PMCID: PMC9293980.
  5. van der Ploeg K, Kirosingh AS, Mori DAM, Chakraborty S, Hu Z, Seivers BL, Jacobson KB, Bonilla H, Parsonnet J, Andrews JR, Press KD, Ty MC, Ruiz-Betancourt DR, de la Parte L, Tan GS, Blish CA, Takahashi S, Rodriguez-Barraquer I, Greenhouse B, Singh U, Wang TT, Jagannathan P. TNFα–producing CD4+ T cells dominate the SARS–CoV–2–specific T cell response in COVID–19 outpatients and are associated with durable antibodies. Cell Rep Med. 2022 Jun 21;3(6):100640. doi: 10.1016/j.xcrm.2022.100640. Epub 2022 May 3. PMID: 35588734.
  6. Jagannathan P, Andrews JR, Bonilla H, Hedlin H, Jacobson KB, Balasubramanian V, et al. Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial. Nature Communications. 12, 1967 (2021). PMCID: PMC8009873.
  7. Zehner N, Adrama H, Kakuru A, Andra T, Kajubi R, Conrad M, Nankya F, Clark TD, Kamya MR, Rodriguez-Barraquer I, Dorsey G, Jagannathan P. Age-related changes in malaria clinical phenotypes during infancy are modified by sickle cell trait. Clin Infect Dis. 2021 Mar 19:ciab245. doi: 10.1093/cid/ciab245. Epub ahead of print. PMID: 33738485. PMCID: PMC8599196.
  8. Kakuru A, Roh M, Kajubi R, Ochieng T, Ategeka J, Ochokoru H, Nakalembe M, Clark TD, Ruel T, Staedke S, Chandramohan D, Havlir DV, Kamya MR, Dorsey G, Jagannathan P. Infant sex modifies associations between placental malaria and risk of malaria in infancy. Malar J. 2020; 19(1):449. PMCID: PMC 7713316
  9. Muhindo M, Jagannathan P, Kakuru A, Opira B, Olwoch P, Okiring J, Nalugo N, Clark TD, Ruel TD, Charlebois ED, Feeney ME, Havlir DV, Kamya MR, Dorsey G. Intermittent preventive treatment with dihydroartemisinin-piperaquine in young Ugandan children and risk of malaria following cessation: A randomised controlled trial. Lancet Inf Dis. 2019 Sep; 19(9):962-972. PMCID: PMC6722008.
  10. Jagannathan P, Kakuru A, Okiring J, Muhindo MK, Natureeba P, Nakalembe M, Opira B, Olwoch, P, Nankya F, Ssewanyana I, Tetteh K, Drakeley C, Beeson J, Reiling L, Clark TD, Rodriguez- Barraquer I, Greenhouse B, Wallender E, Aweeka F, Prahl M, Charlebois ED, Feeney ME, Havlir DV, Kamya MR, Dorsey G. Dihydroartemisinin–piperaquine intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: a randomized controlled trial. PLoS Med. 15(7): e1002606. 2018. PMCID: PMC6049882.

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