Jimena Giudice, PhD

Associate Professor | The University of North Carolina at Chapel Hill
March of Dimes
Jimena Guidice

Jimena Giudice, Associate Professor (with tenure), The University of North Carolina at Chapel Hill,    
Website: https://www.med.unc.edu/cellbiophysio/directory/jimena-giudice-phd/

Biography

Dr. Jimena Giudice is originally from Argentina where she performed her undergraduate and graduate work at the University of Buenos Aires. After an internship in Germany and her postdoctoral training in Baylor College of Medicine, she started her independent research lab in the University of North Carolina at Chapel Hill. Her research focuses on RNA-processing and membrane trafficking in development and diseases. In addition to her degrees in chemical sciences, Dr. Giudice earned a M.Ed. comparable degree and dedicated half of her life to teach in the classroom from kindergarten, into high school, and university. She also had the opportunity to teach in rural areas and to work with homeless community members witnessing how education changes lives, especially in disadvantaged contexts. She was educated in different cultures (Argentina, USA, Germany) and learned microscopy in Switzerland, cell biology in Brazil, and RNA-processing in Italy. International interactions taught her that the perspectives from others expand hers, that collegiality opens doors, and that each person is unique and valuable.

Education

MEd Chemistry Education, comparable University of Buenos Aires, Argentina (2006)

MSc Chemistry, comparable University of Buenos Aires, Argentina (2007)

Internship, Cell Biology and Microscopy, EMBO fellow Mak Planck Institute for Biophysical Chemistry, Germany (2011)

Postdoctoral fellow, Biological Chemistry, Baylor College of Medicine, Houston, USA (2011)

Honors and recognition

EMBO short term fellowship (11/2008 – 4/2008)

PEW Latin American Postdoctoral Fellowship (8/2012 – 2/2016)

American Heart Association Postdoctoral Fellowship (7/2014 – 2/2016)

Basil O’Connor Starter Scholar Research Award from March of Dimes (4/2018 – 3/2020)

Career Development Award from the American Heart Association (4/2019 – 3/2022)

CAREER Award from the National Science Foundation (NSF) (4/2023 – 3/2028)

Selected publications

  1. Giudice J, Xia Z, Wang ET, Ruddy MA, Ward AJ, Kalsotra A, Wang W, Wehrens XHT, Burge CB, Li W, Cooper TA. 2014. Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development. Nature Communications. 5: 3603. doi: 10.1038/ncomms4603. https://pubmed.ncbi.nlm.nih.gov/24752171/
  2. Giudice J*, Loehr JA, Rodney GG, Cooper TA*. (2016). Alternative splicing of four trafficking genes regulates myofiber structure and skeletal muscle physiology. Cell Reports. 17 (8): 1923-1933. doi: 10.1016/j.celrep.2016.10.072. https://pubmed.ncbi.nlm.nih.gov/27851958/
  3. Baralle FE, Giudice J*. 2017. Alternative splicing as a regulator of development and tissue identity. Nature Reviews Molecular Cell Biology. 18 (7): 437-451. doi: 10.1038/nrm.2017.27. REVIEW ARTICLE https://pubmed.ncbi.nlm.nih.gov/28488700/
  4. Smith J#, Curry EG#, Blue RE#, Roden C, Dundon S, Rodríguez-Vargas A, Jordan D, Chen X, Lyons S, Crutchley J, Anderson P, Horb M, Gladfelter A*, Giudice J*. 2020. FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells. Journal of Cell Biology. 219 (4): pii: e201911129. doi: 10.1083/jcb.201911129. https://pubmed.ncbi.nlm.nih.gov/32328638/
  5. Hinkle ER#, Essader TO#, Gentile GM, Giudice J*. 2021. ViaFuse: Fiji macros to calculate skeletal muscle cell viability and fusion index. Skeletal Muscle. 11 (1): 28. doi: 10.1186/s13395-021-00284-3. https://pubmed.ncbi.nlm.nih.gov/34915930/
  6. Wiedner HJ, Giudice J*. 2021. It’s not just a phase: function and characteristics of RNA-binding proteins in phase separation. Nature Structure and Molecular Biology. 28 (6): 465-473. doi: 10.1038/s41594-021-00601-w. REVIEW ARTICLE https://pubmed.ncbi.nlm.nih.gov/34099940/
  7. Hinkle ER#, Wiedner HJ#, Torres EV, Jackson M, Black AJ, Blue RE, Harris SE, Guzman BB, Gentile GM, Lee EY, Tsai Y-H, Parker J, Dominguez D, Giudice J*. 2022. Alternative splicing regulation of membrane trafficking genes during myogenesis. RNA. 28 (4): 523-540. doi: 10.1261/rna.078993.121. https://pubmed.ncbi.nlm.nih.gov/35082143/
  8. Gentile GG#, Gamarra JR#, Engels NM#, Blue RE#, Hoerr I, Wiedner HJ, Hinkle ER, Cote JL, Leverence E, Lee EY, Mills CA, Herring LE, Tan X, Giudice J*. 2022. The synaptosome-associated protein-23 is necessary for proper myogenesis. FASEB Journal. 36 (8): e22441. doi: 10.1096/fj.202101627RR. https://pubmed.ncbi.nlm.nih.gov/35816155/
  9. Wiedner HJ, Torres EV, Blue RE, Tsai Y-H, Parker J, Giudice J*. 2022. SET domain containing 2 (SETD2) influences metabolism and alternative splicing during myogenesis. FEBS Journal. 289 (21): 6799-6816. https://pubmed.ncbi.nlm.nih.gov/35724320/
  10. Hinkle ER, Blue RE, Tsai, Y-H, Combs M, Davi J, Coffey AR, Boriek A, Taylor JM, Parker J, Giudice J*. 2022. Mechanical stretching induces global transcriptional and posttranscriptional transitions and changes in SR proteins in muscle cells. Communication Biology. 5 (1): 987. doi: 10.1038/s42003-022-03915-7.  https://pubmed.ncbi.nlm.nih.gov/36123433/

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