Jamie Lo, MD, MCR

Associate Professor | Oregon Health and Science University
March of Dimes
Jamie Lo

Jamie Lo MD, MCR, Associate Professor, Oregon Health & Science University

Biography

Dr. Jamie Lo is an Associate Professor of Obstetrics and Gynecology and Maternal-Fetal Medicine at Oregon Health & Science University (OHSU). She has joint appointments in the Department of Urology at OHSU and the Division of Reproductive and Developmental Sciences at the Oregon National Primate Research Center. As a physician researcher, her research focuses on the impact of environmental exposures, including substance use, on reproductive health and perinatal outcomes in human cohorts and in non-human primate models. She strives to bring clinical observations to the laboratory with the goal of translating basic scientific findings from the bench to the bedside to increase the understanding of important disease processes and ultimately improve human health. Her work as a March of Dimes Basil O’Connor Scholar, focused on developing a non-human primate model of chronic maternal cannabis use to study the effects of prenatal cannabis exposure on offspring outcomes, including neurodevelopment and sociobehavior. Dr. Lo’s research group focuses on the underlying mechanisms between maternal environmental factors and placental and offspring outcomes using a broad range of methods, including advanced non-invasive imaging techniques and molecular assessments. Dr. Lo is dedicated to the development of physician-scientists, a team-science approach, and the advancement of perinatal and reproductive health research. Her laboratory is funded by the NIH and large foundations.

Education

BA Molecular Cell Biology, Immunology, University of California, Berkeley (2000)

MD Doctor of Medicine, Oregon Health & Science University (2004)

Obstetrics and Gynecology, Residency, University of Utah (2008)

Maternal Fetal Medicine, Fellowship, Oregon Health & Science University (2012)

MCR Masters of Clinical Research, Oregon Health & Science University (2015)

Honors and recognition

March of Dimes Basil O’Connor Starter Scholar Research Award (2020)

Reproductive Scientist Development Program Scholar (2016)

NIH/NIDA Director’s Pioneer Award Program (DP1) Awardee (2022)

Council on Resident Education in Obstetrics and Gynecology (CREOG) National Faculty Award for Excellence in Resident Education (2019)

Co-Director, PMedIC Program (Oregon Health & Science University /Pacific Northwest National Laboratories) (2023)

Selected publications

  1. Shorey-Kendrick LE, Roberts VHJ, D’Mello RJ*, Sullivan EL, Murphy SK, McCarty OJT, Schust DJ, Hedges JC, Mitchell AJ*, Terrobias JJD, Easley CA, Spindel ER, Lo JO. Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes. Clin Epi. 2023. Online ahead of print
  2. Hedges JC#, Hanna CB#, Shorey-Kendrick LE#, Boniface ER, Bash JC, Rice-Stitt TL, Burch FC, D’Mello R, Morgan TK, Lima, AC, Terrobias JJD, Graham JA, Mishler EC, Jensen JV, Hagen OL, Urian W, Spindel ER, Easley CA, Murphy SK, Lo JO. Cessation of chronic delta-9-tetrahydrocannabinol exposure partially reverses impacts on male fertility and the sperm epigenome in rhesus macaques. Fertil Steril. 2023. Online ahead of print
  3. Roberts, VHJ; Schabel, MC; Boniface, ER; D’Mello, RJ; Morgan, TK; Terrobias, JJD; Graham, JA; Borgelt, LM; Grant, KA; Sullivan, EL, Lo, JO. Chronic prenatal delta-9-tetrahydrocannabinol exposure adversely impacts placental function and development in a rhesus macaque model. Sci Reports. 2022;12(1):20260. Doi:10.1038/s41598-022-24401-04. Online ahead of print
  4. Meadows JD, Breuer JA, Lavalle SN, Hirschenberger MR, Meera M. Patel, Nguyen D, Kim A, Jessica Cassin, Gorman MR, Welsh DK, Mellon PL, Hoffmann HM. Deletion of Six3 in post-proliferative neurons produces weakened SCN circadian output, improved metabolic function, and dwarfism in male mice. Mol Metab. 2021 Dec 31;57:101431. PMID: 34974160
  5. Hedges, JC; Hanna, CB; Bash, JC*; Boniface, ER; Burch, FC; Mahalingaiah, S; Roberts, VHJ; Terrobias, JJD; Mishler, EC; Jensen, JV; Easley, CA; Lo, JO. Chronic delta-9-tetrahydrocannabinol exposure impacts testicular volume and male reproductive health in rhesus macaques. Fertil Steril. 2022;117(4):698-707.
  6. Reitsma, SE*; Lakshmanan, HHS; Johnson, J; Pang, J; Parra-Izquierdo, I; Melrose, AR; Choi, J; Hinds, MT; Stevens, JF; Aslan, JE; McCarty, OJT; Lo, JO. Chronic edible dosing of Δ9-tetrahydrocannabinol (THC) in non-human primates reduces systematic platelet activity and function. Am J Physiol Cell Physiol. 2022;322(3):C370-C381.
  7. Lo, JO; Schabel, MC; Roberts, VHJ; Morgan, TK; Fei, SS; Gao, L; Ray, KG; Lewandowski, KS; Newman, NP; Bohn, JA*; Grant, KA; Frias, AE; Kroenke, CD. Effects of early alcohol exposure on placental function and fetal growth in a rhesus macaque model. Am J Obstet Gynecol. 2022;226(1):130.e1-130.e11. Online ahead of print.
  8. Ryan, KS*; Mahalingaiah, S; Campbell, LR*; Roberts, VHJ; Terrobias, JJD; Naito, CS; Boniface, ER; Borgelt, LM; Hedges, JC; Hanna, CB; Hennebold, JD; Lo, JO. The effects of delta-9-tetrahydrocannabinol exposure on female menstrual cyclicity and reproductive health in rhesus macaques. F&S Science. 2021;2(3):287-294.
  9. Lo, JO; Schabel MC; Roberts, VHJ; Wang, X; Lewandowski, KS; Grant, KA; Frias, AE; Kroenke, CD. First trimester alcohol exposure alters placental perfusion and fetal oxygen availability affecting fetal growth and development in a non-human primate model. Am J Obstet Gynecol. 2017;216(3):302.e1-302. PMCID: PMC5334435
  10. Lo, JO; Schabel M; Roberts V; Morgan T; Rasanen J; Kroenke C; Shoemaker S; Spindel E; Grove K; Frias A. Vitamin C supplementation ameliorates the adverse effects of nicotine on placental hemodynamics and histology in non-human primates. Am J Obstet Gynecol. 2015;212(3):370.e1-8. PMCID: PMC4347872