Ethan M. Goldberg, MD, PhD

Assistant Professor | The Children's Hospital of Philadelphia, The University of Pennsylvania Perelman School of Medicine
March of Dimes
Ethan M. Goldberg

Ethan M. Goldberg, MD, PhD, Associate Professor, Director, The Epilepsy Neurogenetics Initiative, Division of Neurology, The Children’s Hospital of Philadelphia, Philadelphia, PA, U.S.A., Departments of Neurology, Neuroscience, & Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, U.S.A.,
Website: https://www.chop.edu/doctors/goldberg-ethan

Biography

Dr. Ethan M. Goldberg is Associate Professor and Attending Physician in the Division of Neurology at The Children’s Hospital of Philadelphia (CHOP) and Departments of Neurology, Neuroscience, and Pediatrics, at The University of Pennsylvania Perelman School of Medicine. He's a practicing pediatric neurologist and neurogeneticist and serves as Director of the Epilepsy Neurogenetics Initiative at CHOP. He runs a basic/translational biomedical research lab studying mechanisms of neurodevelopmental disorders including epilepsy and autism spectrum disorder. Dr. Goldberg is a member of the Mahoney Institute for Neurosciences and the Neuroscience Graduate Group (NGG) and Chair of the NGG M.D./Ph.D. Admissions Committee. He has expertise in ion channel, cellular, and synaptic neurophysiology, functional imaging, mouse and human genetics, and experimental epilepsy. He's interested in how genetic variation leads to neurological disease and the relationship of brain cell type diversity and function and the cellular and circuit basis might underlie developmental brain disorders.

Education

BA, Neurobiology, Harvard University (1999)

PhD, Neuroscience, New York University School of Medicine (2006)

MD, New York University School of Medicine (2008)

Honors and recognition

Burroughs Welcome Fund Career Award for Medical Scientists (2014)

American Society of Clinical Investigation Young Physician-Scientist Award (2017)

March of Dimes Basil O’Connor Research Starter Award (2018)

Grass Foundation - American Neurological Association (ANA)Award in Neuroscience (2019)

Fritz E. Dreifuss Award, American Epilepsy Society (2021)

Selected publications

  1. Goldberg, E.M., Coulter, D.A.: Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction. Nature Reviews Neuroscience 14(5): 337-49, May 2013. PMCID: PMC3982383.
  2. Favero, M., Sotuyo, N.P., Lopez, E., Kearney, J.A., Goldberg, E.M. (2018). A transient developmental window of fast-spiking interneuron dysfunction in a mouse model of Dravet syndrome. The Journal of Neuroscience 38(36): 7912-7927. PMCID: PMC6125809 .
  3. Zaman, T., Helbig, I., Božović, I.B., DeBrosse, S.D., Bergqvist, A.C., Wallis, K., Medne, L., Maver, A., Peterlin, B., Helbig, K.L., Zhang, X., Goldberg, E.M. (2018). Mutations in SCN3A cause early infantile epileptic encephalopathy. Annals of Neurology 83(4): 703-717.
  4. Tran, C.H., Vaiana, M., Nakuci, J., Somarowthu, A., Goff, K.M., Goldstein, N., Murthy, P., Muldoon, S.F., Goldberg, E.M. (2020). Interneuron desynchronization precedes seizures in a mouse model of Dravet syndrome. Journal of Neuroscience 40(13): 2764-2775. PMCID: PMC7096149.
  5. Zaman, T., Helbig, K.L., Clatot, J., Thompson, C.H., Kang, S.K., Stouffs, K., Jansen, A.E., Verstraete, L., Jacquinet, A., Parrini, E., Guerrini, R., Fujiwara, Y., Miyatake, S., Ben-Zeev, B., Bassan, H., Reish, O., Marom, D., Hauser, N., Vu, T.A., Ackermann, S., Spencer, C.E., Lippa, N., Srinivasan, S., Charzewska, A., Hoffman-Zacharska, D., Fitzpatrick, D., Harrison, V., Vasudevan, P., Joss, S., Pilz, D.T., Fawcett, K.A., Helbig, I., Matsumoto, N., Kearney, J.A., Fry, A.E., Goldberg, E.M. (2020). SCN3A-related neurodevelopmental disorder: A spectrum of epilepsy and brain malformation. Ann Neurol 88(2): 348-362.
  6. Goff, K.M., Goldberg, E.M. (2021). A Role for Vasoactive Intestinal Peptide Interneurons in Neurodevelopmental Disorders. Dev Neurosci. 43(3-4):168-180. PMID: 33794534.
  7. Mattis, J., Somarowthu, A., Goff, K.M., Jiang, E., Yom, J., Sotuyo, N., Mcgarry, L.M., Feng, H., Kaneko, K., Goldberg, E.M. (2022). Corticohippocampal circuit dysfunction in a mouse model of Dravet syndrome. Elife. Feb 25;11:e69293. doi: 10.7554/eLife.69293. PMID: 35212623.
  8. Kaneko, K., Currin, C.B., Goff, K.M., Somarowthu, A., Vogels, T.P., Goldberg, E.M. (2022). Developmentally-regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome. Cell Rep. Mar 29;38(13):110580. doi: 10.1016/j.celrep.2022.110580. PMID: 35354025. PMCID: PMC9003081.
  9. Clatot, J., Ginn, N., Costain, G., Goldberg, E.M. (2023). A KCNC1-related neurological disorder due to gain of Kv3.1 function. Ann Clin Transl Neurol. 2022 Nov 23. doi: 10.1002/acn3.51707. PMID: 36419348.
  10. Goff, K.M, Liebergall, S.L., Jiang, E., Somarowthu, S., Goldberg, E.M. (2023). VIP interneuron impairment promotess drive in vivo circuit dysfunction and autism-related behaviors in Dravet syndrome. Cell Reports. 42(6):112628. PMID: 37310860.

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